Paul Stamets: The Power of Psilocybin Mushrooms and Indigenous Wisdom

In this video, Paul Stamets, a renowned mycologist and knowledge keeper of indigenous wisdom, discusses the potential of psilocybin mushrooms. He highlights the convergence of indigenous knowledge and scientific research, indicating that studies are validating the benefits of these sacred medicines that have been used for thousands of years. Stamets emphasizes the need for clinical trials and regulation, as well as the importance of protecting indigenous cultures. He presents evidence of the positive impact of psilocybin in reducing crime, depression, anxiety, and even opioid use disorder. Stamets urges the medical and scientific communities to embrace psilocybin as a game-changer in mental health.

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Key Insights:

  • Psilocybin mushrooms have been part of indigenous knowledge and sacred medicine for thousands of years.
  • The convergence of indigenous wisdom and scientific research is validating the traditional usage of psilocybin mushrooms.
  • There are over 140 known species of psilocybin mushrooms worldwide, with the exception of Antarctica.
  • Mushrooms have been less studied compared to plants or animals due to their ephemeral nature and sporadic appearance.
  • Historical evidence of psilocybin mushroom use can be found in Mesoamerican mushroom stones and ancient cave art.
  • Maria Sabina, an indigenous shaman, played a crucial role in introducing psilocybin mushrooms to the world.
  • Scientific research on psilocybin has shown potential therapeutic benefits in treating depression, anxiety, addiction, and reducing violent crime.
  • Microdosing psilocybin mushrooms, along with other compounds like niacin and Lion’s Mane, may have potential cognitive and neurogenic benefits.
  • Psilocybin has shown promising results in reducing opioid and alcohol use disorders.
  • Psilocybin has the potential to enhance empathy, kindness, and community building.
  • Legal frameworks and regulations are necessary to ensure the safe and responsible use of psilocybin.
  • Clinical trials of psilocybin need new approaches to define placebo control and ethics for patients with treatment-resistant conditions.
  • Collaboration between indigenous knowledge keepers, researchers, and clinicians is crucial in harnessing the full potential of psilocybin mushrooms.


Greetings folks, I’m Paul Stamets, a knowledge keeper representing a community of indigenous people who have preserved, studied, and shared the sacred medicines of psilocybin mushrooms. I want to share with you the cutting-edge research that validates indigenous wisdom and the convergence of science and indigenous knowledge. I want to disclose that I own, a company specializing in fungi, and I have founded a startup called MicroMedic Life Sciences, focusing on therapeutic use of psilocybin. I also have a non-profit organization called the Center for Ecological Consciousness. Currently, 141 species of psilocybin mushrooms have been discovered globally, except in Antarctica. These mushrooms are ephemeral, appearing and disappearing within a few days, making them challenging to study. However, their presence has been recorded in archaeological records and ancient texts, such as Mesoamerican mushroom stones and the myth of Demeter. I acknowledge the contributions of Maria Sabina, an indigenous shaman and mycologist who shared her knowledge with researchers. Scientists such as Richard Evans Schultes and Albert Hoffman played crucial roles in taxonomy and discovering the molecule psilocybin within these mushrooms. Personally, I have written books on psilocybin mushrooms, discovered and co-authored new species, and even have a mushroom species named after me. Psilocybin mushrooms have become an integral part of our cultural zeitgeist, with clinical studies demonstrating their potential benefits in treating depression, reducing crime, and aiding in addiction recovery. Currently, there are over 120 clinical trials registered on, investigating the therapeutic effects of psilocybin. These trials have shown significant results in reducing depression, anxiety, and substance abuse disorders. Microdosing psilocybin, as a sub-perceptual dose, has also gained popularity and has shown positive effects on mood and cognitive function. I have personally been involved in a microdosing study, which demonstrated improved psychomotor skills in subjects over the age of 55. The mechanisms of action behind these effects are still being studied, but there is evidence to suggest that a combination of psilocybin, niacin, and lion’s mane mushroom may play a role in stimulating nerve growth factors, reducing neurodegeneration, and improving the immune system. Nevertheless, further clinical trials are needed to solidify these findings. I believe that psilocybin is a game changer that has the potential to reduce crime, improve mental health, and bring communities together. However, it must be approached responsibly, and regulations and quality controls need to be implemented to ensure safety and efficacy. The field of psychedelic research is still in its early stages, and imaginative approaches are required to push the boundaries of knowledge and achieve breakthroughs. Minorities and indigenous cultures with their rich biodiversity and knowledge play a vital role in shaping the future of medicine and science. We are at a crucial point in human evolution where we need to make conscious decisions that will impact future generations. Legal frameworks and regulations should be put in place to support further research on psychedelics, while also protecting the rights and knowledge of indigenous communities. Psilocybin has the potential to change our society for the better, and I urge everyone involved in this movement to work together, fostering kindness, courage, and wisdom. Psilocybin is a sacred medicine that needs to be treated as such.