The Role of GABA in Neurotransmission and its Benefits

In this video, Dr. Scott discusses the importance of GABA, a neurotransmitter responsible for relaxation and maintaining a balance between excitation and relaxation in the brain. He explains that 80% of neurotransmission is related to the balance between glutamate (excitatory neurotransmitter) and GABA. Depletion of GABA can lead to symptoms such as depression, anxiety, poor sleep, and even physical issues like tremors. Dr. Scott suggests ways to support GABA levels, including getting enough glutamine and magnesium in the diet, practicing relaxation techniques like meditation and breathwork, and using natural supplements like valerian root, kava, and agarn. He also mentions TroScriptions, a company he is associated with, that offers products to support GABA function and improve sleep and relaxation.

Author Icon

Our Summaries are written by our own AI Infrastructure, to save you time on your Health Journey!

How does this happen?

Key Insights:

  • GABA is a neurotransmitter responsible for relaxation and allowing the brain to relax.
  • The balance between glutamate and GABA is crucial for neurotransmission in the brain.
  • GABA deficiency can lead to symptoms such as depression, anxiety, poor sleep, tremors, and mood fluctuations.
  • Glutamine is an amino acid that is converted to glutamate in the brain, which then gets converted to GABA.
  • Dietary sources of glutamine, such as meat and organ meats, are important for GABA synthesis.
  • Stress, infections, and certain medications can deplete GABA levels.
  • Supplementation with substances like valerian root, kava, agarin from the amanita musara mushroom, and nicotin GABA can enhance GABA production.
  • Relaxation techniques like meditation, breathwork, and yoga can also support GABA production.
  • Improving GABA levels can have a positive impact on sleep, performance, and overall well-being.
  • It is important to optimize other factors like diet, lifestyle, and stress management to fully support the GABA system.


Dr. Scott focuses on discussing cutting-edge topics and promising supplements. He highlights the importance of exploring what’s upcoming and the literature to understand where things are headed. In this video, they discuss a neurotransmitter called GABA, its benefits, applications, and depletion in the body.

GABA, which stands for gamma-aminobutyric acid, is a neurotransmitter responsible for relaxation and allowing the brain to relax. It plays a crucial role in balancing neurotransmission with another neurotransmitter called glutamate. Glutamate stimulates the brain, making you feel awake and ready, while GABA promotes relaxation. The balance between these two neurotransmitters is essential for both excitement and relaxation.

When there is a GABA deficiency, various symptoms can occur, including depression, anxiety, stress, poor sleep, tremors, difficulties with urination, and emotional instability. Many people are under constant stress, depleting their stress neurotransmitters and glutamate, which impacts GABA levels.

One way GABA can become depleted is through stress, including infections and overtraining. Glutamine, an amino acid, is the precursor to glutamate, which then converts into GABA in the brain. Therefore, a deficiency in glutamine can prevent the production of enough GABA in the brain. Vegetarians and vegans often struggle to obtain enough glutamine in their diet. Athletes who overtrain may deplete glutamine and GABA, resulting in irritability, poor sleep, anxiety, and depression.

To support GABA levels, it is crucial to ensure an adequate intake of glutamine-rich foods, such as meat. Additionally, it is essential to have sufficient magnesium and vitamin B6, as they are necessary co-factors for GABA conversion. Other ways of enhancing GABA production include herbal supplements like valerian root and kava, and even certain mushrooms like Amanita muscaria. Meditation, breathwork, and yoga can also help balance the sympathetic and parasympathetic nervous systems, promoting GABA production.

When supplementing GABA, it is important to note that GABA supplements themselves do not effectively cross the blood-brain barrier unless leaky gut issues exist. Therefore, it is recommended to explore alternatives such as valerian root, kava, or Amanita muscaria extracts that have positive effects on GABA receptors. These compounds can enhance GABA binding or positively modulate GABA binding sites, leading to increased GABA transmission.

GABA support is not limited to sleep; it also helps maintain the balance between the sympathetic and parasympathetic nervous systems throughout the day. By increasing GABA levels and promoting relaxation, individuals can enhance their performance, manage stress, and improve recovery. Slow down, find ways to relax, incorporate stress-reducing activities like breathwork, yoga, or meditation, and ensure a nutrient-dense diet to support GABA production.

Dr. Scott suggests using interventions to reset the system in cases where stress and toxic environments are overwhelming. These interventions may include supplements or medications that help calm the mind and body, allowing for relaxation and control. While the ultimate goal is to optimize health and reduce dependence on exogenous substances, these interventions can be valuable steps towards achieving that goal.

In conclusion, GABA plays a critical role in neurotransmission by promoting relaxation and modulating the balance between excitatory and inhibitory neurotransmitters. Enhancing GABA production through diet, lifestyle changes, and natural supplements can help manage stress, improve sleep, and enhance overall well-being.