The latest human trial on NMN supplementation revealed unexpected results due to the low dosage used. The study involved 36 middle-aged adults and aimed to evaluate the effects of NMN on various health parameters. Surprisingly, the subjects were only given 125 milligrams of NMN twice daily, a significantly lower dosage compared to what is commonly used. Despite the low dosage, the study found that NMN supplementation reduced arterial stiffness, indicating a decrease in cardiovascular disease risk. However, no significant differences were observed in other health markers. The study authors suggested that higher dosages and more participants may yield even greater benefits.
Key Insights:
- The study investigated the effects of oral NMN supplementation on various biochemical and metabolic health parameters.
- The trial involved 36 middle-aged adults and lasted for 12 weeks.
- The dosage used in the study was only 125 milligrams of NMN administered twice daily, which is much lower than the common daily dosage of 1 to 1.5 grams.
- The effects of NMN on human vascular dysfunction were evaluated by measuring pulse wave velocity values, which indicate arterial stiffness.
- The study found that NMN supplementation at the low dosage reduced arterial stiffness, indicating a potential reduction in cardiovascular disease risk.
- No significant differences were observed between the NMN and placebo groups in terms of age and health-related markers.
- The study authors concluded that long-term NMN supplementation is safe, beneficial for activating NAD metabolism, and reduces arterial stiffness.
- Increasing the NMN dosage and the number of trial participants may yield more evident effects on human health.
- Metabolic disorders play a crucial role in most cardiovascular diseases, and NMN supplementation enhances metabolic stability, reducing cardiovascular disease risk.
- The results of the trial may have been different if higher dosages were administered.
- A 10% discount code for NMN products is offered by the team at „Do Not Age.“
- Higher dosages of NMN are commonly used for health and longevity purposes, and further benefits are expected based on previous studies.
Transcript
I’ve just finished looking over the latest NMN human trial which investigated the effects of oral NMN supplementation on various biochemical and metabolic health parameters, and I think you’re going to find the results to be somewhat unexpected, especially when you hear how little NMN study subjects were actually given.
Thank you. This latest human NMN study was published only a few months ago on February 16th and it was a 12-week randomized double-blind placebo-controlled trial involving 36 middle-aged adults. Now, the trial sought to evaluate the efficacy of NMN supplementation with regard to several health parameters, including blood pressure, liver function, vascular stiffness, and serum concentrations of NAD, Nam, and CERT1.
Now, when I first read through this trial, the first thing that struck me about it was the extremely low dosage used, only 125 milligrams of NMN administered twice daily in capsule form. Compare this to the common daily dosage of 1 to 1.5 grams taken by most users of the supplement, and it does make you wonder just how much of any pre-trial research and effect of dosage and protocols actually took place. We already know through the work of Dr. David Sinclair and others that NMN’s effects are dose-dependent, at least up to a point, with a typical starting dosage of around one gram per day and an upper daily limit of around 2 grams, above which there appears to be little further benefit. But why such a low dosage was chosen for evaluation in this particular study is unclear.
Now, although NMN supplementation had previously been shown to improve age-associated vascular dysfunction in mice, its effects on human vascular dysfunction had not yet been validated, and this was one objective of the study. The researchers measured what’s called pulse wave velocity values, which are considered to be an accurate measure of arterial stiffness. Specifically, they measured brachial ankle pulse wave velocity, or baPWV. A previous meta-analysis found that the risk of cardiovascular events associated with high baPWV is almost three times greater than that associated with a low value. As you can see from the graph, those baPWV values tended to decrease in the NMN intake group, indicating a reduction in arterial stiffness. The fact that NMN is achieving this at such a low dosage is very encouraging, and I should also point out that the greatest reduction in baPWV values were experienced by those in the NMN group with above-average body mass index or blood glucose levels.
Several age and health-related markers were also measured, including CERT1 expression, advanced location end products in the skin, and 8-OHdG, which is a specific marker of oxidative damage to DNA. However, in this instance, no statistically significant differences were observed between the NMN and placebo groups.
The study authors concluded that long-term NMN supplementation in healthy middle-aged individuals is safe, beneficial for activating NAD metabolism, and reduces arterial stiffness with a corresponding reduction in cardiovascular disease risk. They also accepted that more evident effects of NMN on human health might be observed by increasing both the NMN dose and the number of trial participants.
Metabolic disorders play a crucial role in most cardiovascular diseases, and we know that sufficient NAD+ is an essential requirement for the proper functioning of our metabolic pathways. Supplementing with an NAD precursor such as NMN reduces our cardiovascular disease risk by enhancing metabolic stability, and that one benefit alone might just be a lifesaver for some. I’d be very interested to know what the results of the trial would have been if they had administered higher dosages that were more in line with those commonly used for health and longevity. I think you’ll agree that based on previous study data, further benefits would be the most likely outcome.
And while on the subject of higher dosages, here’s a very useful 10% discount code, courtesy of the team at „Do Not Age.“ And that code will work not only for the third-party lab-tested NMN but for any product in the range. I’ve been taking NMN since it first hit the market, and I refuse to buy anything other than pure pharmaceutical capsules, and this „Do Not Age“ product meets my requirements perfectly.
Many thanks for watching, and if you haven’t already done so, then click that subscribe button to keep up with all this news on health and longevity. And lastly, as always, take care, be healthy, and see you again soon. Thank you.
